Beyond Antibodies: The DARPin Platform

The DARPin drug platform was established with a imaginative and prescient to develop the medical use of biologics past what was doable with monoclonal antibodies. It’s based mostly on naturally occurring ankyrin repeat domains which might be usually constructing blocks of multifunctional human proteins.

 

The platform permits for the era of various, well-behaved, multifunctional drug candidates. Current scientific knowledge illustrate the favorable security profile of the primary DARPin® molecules examined in sufferers. With the optimistic part III outcomes of essentially the most superior DARPin® drug candidate, abicipar, the DARPin® drug platform is doubtlessly about to realize its first advertising and marketing approval.

               

Genscanner
Genscanner

                     
This assessment highlights a few of the key milestones and selections encountered when reworking the DARPin® platform from an educational idea to a biotech drug pipeline engine.

Coexisting TIF1γ-positive Main Pulmonary Lymphoepithelioma-like Carcinoma and Anti-TIF1γ Antibody-positive Dermatomyositis: A Case Report

                     

Anti-transcriptional middleman issue 1γ (anti-TIF1γ) antibody-positive dermatomyositis (DM) is strongly related to most cancers, though the mechanism of motion continues to be unclear. We herein describe the primary recognized case of an 80-year-old lady recognized with TIF1γ-positive main pulmonary lymphoepithelioma-like carcinoma (LELC) coexisting with anti-TIF1γ antibody-positive DM.

Antibody for Human RAGE

SPC-1292D-A390 0.1ml
EUR 433.2
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 390.

Antibody for Human RAGE

SPC-1292D-A488 0.1ml
EUR 432
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 488.

Antibody for Human RAGE

SPC-1292D-A565 0.1ml
EUR 432
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 565.

Antibody for Human RAGE

SPC-1292D-A594 0.1ml
EUR 432
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 594.

Antibody for Human RAGE

SPC-1292D-A633 0.1ml
EUR 432
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 633.

Antibody for Human RAGE

SPC-1292D-A655 0.1ml
EUR 432
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 655.

Antibody for Human RAGE

SPC-1292D-A680 0.1ml
EUR 432
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 680.

Antibody for Human RAGE

SPC-1292D-A700 0.1ml
EUR 432
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 700.

Antibody for Human RAGE

SPC-1292D-ALP 0.1ml
EUR 426
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Alkaline Phosphatase.

Antibody for Human RAGE

SPC-1292D-APC 0.1ml
EUR 430.8
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to APC .

Antibody for Human RAGE

SPC-1292D-APCCY7 0.1ml
EUR 518.4
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to APC/Cy7.

Antibody for Human RAGE

SPC-1292D-BI 0.1ml
EUR 428.4
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Biotin.

Antibody for Human RAGE

SPC-1292D-DY350 0.1ml
EUR 523.2
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Dylight 350.

Antibody for Human RAGE

SPC-1292D-DY405 0.1ml
EUR 494.4
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Dylight 405.

Antibody for Human RAGE

SPC-1292D-DY488 0.1ml
EUR 471.6
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Dylight 488.

Antibody for Human RAGE

SPC-1292D-DY594 0.1ml
EUR 476.4
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Dylight 594.

Antibody for Human RAGE

SPC-1292D-DY633 0.1ml
EUR 464.4
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Dylight 633.

Antibody for Human RAGE

SPC-1292D-FITC 0.1ml
EUR 423.6
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to FITC.

Antibody for Human RAGE

SPC-1292D-HRP 0.1ml
EUR 418.8
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to HRP.

Antibody for Human RAGE

SPC-1292D-P594 0.1ml
EUR 440.4
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to PE/ATTO 594.

Antibody for Human RAGE

SPC-1292D-PCP 0.1ml
EUR 430.8
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to PerCP.

Antibody for Human RAGE

SPC-1292D-RPE 0.1ml
EUR 429.6
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to RPE .

Antibody for Human RAGE

SPC-1292D-STR 0.1ml
EUR 430.8
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Streptavidin.

Anti Human RAGE Monoclonal Antibody (Clone No. 1C5)

KG134 each
EUR 856.8
Description: The Anti Human RAGE Monoclonal Antibody (Clone No. 1C5) is available in Europe and for worldwide shipping via Gentaur.

RAGE, human recombinant

4271-10 each
EUR 222

RAGE, human recombinant

4271-1000 each
EUR 5018.4

RAGE, human recombinant

4271-50 each
EUR 510

Human RAGE ELISA Kit

55R-1764 1 kit
EUR 805.2
Description: ELISA kit for detection of RAGE in the research laboratory

Human Rage ELISA kit

LF-EK50731 1×96T
EUR 790.8

Human RAGE ELISA Kit

EHR0356 96Tests
EUR 625.2

Human RAGE ELISA Kit

E28L0561 96T
EUR 666.67

Human RAGE Fast ELISA

TBS3247 1x96-well plate
EUR 580
Description: Cell culture Supernate, Plasma/Serum RAGE

RAGE (Human) ELISA Kit

EKA52061-5x96T 5x96T Ask for price

RAGE (Human) ELISA Kit

EKA52061-96T 96T
EUR 446.9

ELISA kit for Human Rage

EK5367 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Rage in samples from serum, plasma, tissue homogenates and other biological fluids.

RAGE antibody

20R-RG001 250 ul
EUR 418.8
Description: Goat polyclonal RAGE antibody

RAGE antibody

20R-RG002 250 ul
EUR 484.8
Description: Goat polyclonal RAGE antibody

RAGE antibody

20R-RR001 100 ug
EUR 807.6
Description: Rabbit polyclonal RAGE antibody

RAGE Antibody

29058-100ul 100ul
EUR 302.4

RAGE antibody

38298-100ul 100ul
EUR 302.4

RAGE antibody

70R-RG006 100 ug
EUR 360
Description: Affinity purified Goat polyclonal RAGE antibody

RAGE antibody

70R-RG007 100 ug
EUR 360
Description: Affinity purified Goat polyclonal RAGE antibody

RAGE antibody

70R-9435 50 ug
EUR 560.4
Description: Affinity purified rabbit polyclonal RAGE antibody

RAGE Antibody

49341-100ul 100ul
EUR 399.6

RAGE Antibody

49341-50ul 50ul
EUR 286.8

RAGE antibody

70R-13753 100 ug
EUR 366
Description: Affinity purified Goat polyclonal RAGE antibody

RAGE antibody

70R-15273 100 ug
EUR 392.4
Description: Rabbit polyclonal RAGE antibody

RAGE antibody

70R-1663 100 ug
EUR 452.4
Description: Rabbit polyclonal AGER antibody raised against the C terminal of AGER

RAGE antibody

70R-5975 50 ug
EUR 560.4
Description: Rabbit polyclonal AGER antibody raised against the N terminal of AGER

RAGE antibody

70R-5978 50 ug
EUR 560.4
Description: Rabbit polyclonal AGER antibody raised against the C terminal of AGER

RAGE antibody

70R-4337 50 ug
EUR 560.4
Description: Rabbit polyclonal RAGE antibody raised against the N terminal of RAGE

RAGE Antibody

ABD6618 100 ug
EUR 525.6

Rage Antibody

F43706-0.08ML 0.08 ml
EUR 140.25
Description: RAGE, the 'receptor for advanced glycation endproducts' is a transmembrane receptor of the immunoglobulin super family. The interaction between RAGE and its ligands, AGE and HMGB1, is thought to result in pro-inflammatory gene activation. Due to an enhanced level of RAGE ligands in diabetes or other chronic disorders, this receptor is hypothesised to have a causative effect in a range of inflammatory diseases such as diabetic complications, Alzheimer's disease and even some tumors. [Wiki]

Rage Antibody

F43706-0.4ML 0.4 ml
EUR 322.15
Description: RAGE, the 'receptor for advanced glycation endproducts' is a transmembrane receptor of the immunoglobulin super family. The interaction between RAGE and its ligands, AGE and HMGB1, is thought to result in pro-inflammatory gene activation. Due to an enhanced level of RAGE ligands in diabetes or other chronic disorders, this receptor is hypothesised to have a causative effect in a range of inflammatory diseases such as diabetic complications, Alzheimer's disease and even some tumors. [Wiki]

RAGE Antibody

F48036-0.08ML 0.08 ml
EUR 140.25
Description: RAGE/AGER is a member of the immunoglobulin superfamily of cell surface molecules. It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products.

RAGE Antibody

F48036-0.4ML 0.4 ml
EUR 322.15
Description: RAGE/AGER is a member of the immunoglobulin superfamily of cell surface molecules. It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products.

RAGE Antibody

F48037-0.08ML 0.08 ml
EUR 140.25
Description: This gene encodes a member of the immunoglobulin superfamily of cell surface molecules. It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products. The gene lies within the major histocompatibility complex (MHC) class III region on chromosome 6.

RAGE Antibody

F48037-0.4ML 0.4 ml
EUR 322.15
Description: This gene encodes a member of the immunoglobulin superfamily of cell surface molecules. It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products. The gene lies within the major histocompatibility complex (MHC) class III region on chromosome 6.

RAGE Antibody

F49953-0.08ML 0.08 ml
EUR 140.25
Description: RAGE is able to phosphorylate several exogenous substrates and to undergo autophosphorylation.

RAGE Antibody

F49953-0.4ML 0.4 ml
EUR 322.15
Description: RAGE is able to phosphorylate several exogenous substrates and to undergo autophosphorylation.

RAGE Antibody

R30250 100 ug
EUR 356.15
Description: The receptor for advanced glycation end products(RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. It interacts with distinct molecules implicated in homeostasis, development and inflammation, and certain diseases such as diabetes and Alzheimers disease. RAGE is also a central cell surface receptor for amphoterin and EN-RAGE. RAGE is associated with sustained NF-kappaB activation in the diabetic microenvironment and has a central role in sensory neuronal dysfunction. Moreover, RAGE propagates cellular dysfunction in several inflammatory disorders and diabetes, and it also functions as an endothelial adhesion receptor promoting leukocyte recruitment.

RAGE Antibody

R32232 100 ug
EUR 356.15
Description: The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. It interacts with distinct molecules implicated in homeostasis, development and inflammation, and certain diseases such as diabetes and Alzheimer's disease. RAGE is also a central cell surface receptor for amphoterin and EN-RAGE. And RAGE is associated with sustained NF-kappaB activation in the diabetic microenvironment and has a central role in sensory neuronal dysfunction. Moreover, RAGE propagates cellular dysfunction in several inflammatory disorders and diabetes, and it also functions as an endothelial adhesion receptor promoting leukocyte recruitment.

RAGE Antibody

E91786 100ul
EUR 255
Description: Available in various conjugation types.

RAGE Antibody

49341 100ul
EUR 499

RAGE antibody

38298 100ul
EUR 439

RAGE

MO15029 500 ug
EUR 1092

RAGE

GT15030 100 ug
EUR 631.2

RAGE

E8ET1702-27 100ul
EUR 275
Description: Available in various conjugation types.

Human Rage ELISA kit (4X96T)

LF-EK50732 4×96T
EUR 2690.4

RAGE 229

466265 5.0mg
EUR 440

RAGE 229

T61721-10mg 10mg Ask for price
Description: RAGE 229

RAGE 229

T61721-1g 1g Ask for price
Description: RAGE 229

RAGE 229

T61721-1mg 1mg Ask for price
Description: RAGE 229

RAGE 229

T61721-50mg 50mg Ask for price
Description: RAGE 229

RAGE 229

T61721-5mg 5mg Ask for price
Description: RAGE 229

Human Renal Tumor Antigen (RAGE) Protein

20-abx068860
  • EUR 794.40
  • EUR 326.40
  • EUR 2448.00
  • EUR 944.40
  • EUR 577.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Rage PicoKine ELISA Kit

EK0827 96 wells
EUR 583.2
Description: For quantitative detection of human Rage in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

                       

The prognosis of LELC can solely be made by a surgical lung biopsy, and never by a computed tomography-guided biopsy, due to heavy lymphocytic infiltration. This instructive case reaffirmed the significance of energetic screening for malignancy in sufferers with anti-TIF1γ antibody-positive DM.

                       

Curiously, the outcomes additionally advised that the robust relationship which exists between anti-TIF1γ antibody-positive DM and most cancers is doubtlessly attributable to tumor-derived TIF1γ.

                       

Worth of Space Postrema Syndrome in Differentiating Adults With AQP4 vs. MOG Antibodies

Targets: To match the frequency of space postrema syndrome (APS) in adults with anti-aquaporin-4 (AQP4) and anti-myelin oligodendrocyte glycoprotein (MOG) antibodies.

                       

Strategies: APS is outlined as acute or subacute, single or mixed, episodic or fixed nausea, vomiting, or hiccups, persisting for not less than 48 h, which can’t be attributed to some other etiology. The presence of APS was investigated in 274 adults with AQP4 antibodies and 107 adults with MOG antibodies from 10 hospitals. ‘

                       

Outcomes: The research inhabitants comprised Korean adults (≥18 years). On the time of illness onset, 14.9% (41/274) adults with AQP4 antibodies had APS, whereas not one of the individuals with MOG antibodies developed APS (p < 0.001). Throughout the course of the illness, 17.2% (47/274) adults with AQP4 antibodies had APS in distinction to 1.9% (2/107) adults with MOG antibodies with APS (p < 0.001).

                       

Recombinant Human Resistin

7-01521 1mg Ask for price

Canine Resistin(Resistin) ELISA Kit

QY-E70171 96T
EUR 511.2

human Resistin ELISA KIT

201-12-0339 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Resistin ELISA kit

55R-1714 1 kit
EUR 805.2
Description: ELISA kit for the detection of Human Resistin in the research laboratory

Human Resistin ELISA kit

55R-2127 96 tests
EUR 919.2
Description: ELISA Kit for detection of Resistin in the research laboratory

Human Resistin ELISA kit

55R-E50 96 wells
EUR 1413.6
Description: ELISA kit for the detection of Human Resistin in the research laboratory

human Resistin ELISA KIT

CN-04165H1 96T
EUR 530.4

human Resistin ELISA KIT

CN-04165H2 48T
EUR 351.6

Human Resistin ELISA KIT

CSB-E06884h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Resistin in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Resistin ELISA KIT

1-CSB-E06884h
  • EUR 722.40
  • EUR 5085.60
  • EUR 2707.20
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Resistin in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

                      

Conclusions: APS, one of many core scientific traits of people with AQP4 antibodies, is an especially uncommon manifestation in Korean adults with MOG antibodies.