The DARPin drug platform was established with a imaginative and prescient to develop the medical use of biologics past what was doable with monoclonal antibodies. It’s based mostly on naturally occurring ankyrin repeat domains which might be usually constructing blocks of multifunctional human proteins.
The platform permits for the era of various, well-behaved, multifunctional drug candidates. Current scientific knowledge illustrate the favorable security profile of the primary DARPin® molecules examined in sufferers. With the optimistic part III outcomes of essentially the most superior DARPin® drug candidate, abicipar, the DARPin® drug platform is doubtlessly about to realize its first advertising and marketing approval.
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This assessment highlights a few of the key milestones and selections encountered when reworking the DARPin® platform from an educational idea to a biotech drug pipeline engine.
Coexisting TIF1γ-positive Main Pulmonary Lymphoepithelioma-like Carcinoma and Anti-TIF1γ Antibody-positive Dermatomyositis: A Case Report
Anti-transcriptional middleman issue 1γ (anti-TIF1γ) antibody-positive dermatomyositis (DM) is strongly related to most cancers, though the mechanism of motion continues to be unclear. We herein describe the primary recognized case of an 80-year-old lady recognized with TIF1γ-positive main pulmonary lymphoepithelioma-like carcinoma (LELC) coexisting with anti-TIF1γ antibody-positive DM.
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 488.
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 565.
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 594.
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 633.
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 655.
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 680.
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 700.
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Alkaline Phosphatase.
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to APC .
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to APC/Cy7.
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Biotin.
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Dylight 350.
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Dylight 405.
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Dylight 488.
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Dylight 594.
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Dylight 633.
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to FITC.
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to HRP.
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to PE/ATTO 594.
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to PerCP.
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to RPE .
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Streptavidin.
Description: RAGE, the 'receptor for advanced glycation endproducts' is a transmembrane receptor of the immunoglobulin super family. The interaction between RAGE and its ligands, AGE and HMGB1, is thought to result in pro-inflammatory gene activation. Due to an enhanced level of RAGE ligands in diabetes or other chronic disorders, this receptor is hypothesised to have a causative effect in a range of inflammatory diseases such as diabetic complications, Alzheimer's disease and even some tumors. [Wiki]
Description: RAGE, the 'receptor for advanced glycation endproducts' is a transmembrane receptor of the immunoglobulin super family. The interaction between RAGE and its ligands, AGE and HMGB1, is thought to result in pro-inflammatory gene activation. Due to an enhanced level of RAGE ligands in diabetes or other chronic disorders, this receptor is hypothesised to have a causative effect in a range of inflammatory diseases such as diabetic complications, Alzheimer's disease and even some tumors. [Wiki]
Description: RAGE/AGER is a member of the immunoglobulin superfamily of cell surface molecules. It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products.
Description: RAGE/AGER is a member of the immunoglobulin superfamily of cell surface molecules. It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products.
Description: This gene encodes a member of the immunoglobulin superfamily of cell surface molecules. It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products. The gene lies within the major histocompatibility complex (MHC) class III region on chromosome 6.
Description: This gene encodes a member of the immunoglobulin superfamily of cell surface molecules. It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products. The gene lies within the major histocompatibility complex (MHC) class III region on chromosome 6.
Description: The receptor for advanced glycation end products(RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. It interacts with distinct molecules implicated in homeostasis, development and inflammation, and certain diseases such as diabetes and Alzheimers disease. RAGE is also a central cell surface receptor for amphoterin and EN-RAGE. RAGE is associated with sustained NF-kappaB activation in the diabetic microenvironment and has a central role in sensory neuronal dysfunction. Moreover, RAGE propagates cellular dysfunction in several inflammatory disorders and diabetes, and it also functions as an endothelial adhesion receptor promoting leukocyte recruitment.
Description: The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. It interacts with distinct molecules implicated in homeostasis, development and inflammation, and certain diseases such as diabetes and Alzheimer's disease. RAGE is also a central cell surface receptor for amphoterin and EN-RAGE. And RAGE is associated with sustained NF-kappaB activation in the diabetic microenvironment and has a central role in sensory neuronal dysfunction. Moreover, RAGE propagates cellular dysfunction in several inflammatory disorders and diabetes, and it also functions as an endothelial adhesion receptor promoting leukocyte recruitment.
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Rage in samples from serum, plasma, tissue homogenates and other biological fluids.
Description: Description of target: RAGE, the Receptor for Advanced Glycation Endproducts, is a 35kD transmembrane receptor of the immunoglobulin super family. It is also known as “AGERâ€. AGER gene is mapped to chromosome 6p21.3 by mapping by contiguous cosmids and YAC clones and by fluorescence in situ hybridization. The expression of RAGE is particularly increased in neurons close to deposits of amyloid beta peptide and to neurofibrillary tangles. RAGE has been linked to several chronic diseases, which are thought to result from vascular damage. The pathogenesis is hypothesized to include ligand binding upon which RAGE signals activation of the nuclear factor kappa B (NF-κB).;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 10 pg/ml
Description: Description of target: This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene.;Species reactivity: Human;Application: ;Assay info: Quantitative Sandwich ELISA;Sensitivity: < 0.066 ng/mL
Description: A sandwich quantitative ELISA assay kit for detection of Human Renal Tumor Antigen (RAGE) in samples from tissue homogenates, cell lysates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Human Renal Tumor Antigen (RAGE) in samples from tissue homogenates, cell lysates or other biological fluids.
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The prognosis of LELC can solely be made by a surgical lung biopsy, and never by a computed tomography-guided biopsy, due to heavy lymphocytic infiltration. This instructive case reaffirmed the significance of energetic screening for malignancy in sufferers with anti-TIF1γ antibody-positive DM.
Curiously, the outcomes additionally advised that the robust relationship which exists between anti-TIF1γ antibody-positive DM and most cancers is doubtlessly attributable to tumor-derived TIF1γ.
Worth of Space Postrema Syndrome in Differentiating Adults With AQP4 vs. MOG Antibodies
Targets: To match the frequency of space postrema syndrome (APS) in adults with anti-aquaporin-4 (AQP4) and anti-myelin oligodendrocyte glycoprotein (MOG) antibodies.
Strategies: APS is outlined as acute or subacute, single or mixed, episodic or fixed nausea, vomiting, or hiccups, persisting for not less than 48 h, which can’t be attributed to some other etiology. The presence of APS was investigated in 274 adults with AQP4 antibodies and 107 adults with MOG antibodiesfrom 10 hospitals. ‘
Outcomes: The research inhabitants comprised Korean adults (≥18 years). On the time of illness onset, 14.9% (41/274) adults with AQP4 antibodies had APS, whereas not one of the individuals with MOG antibodies developed APS (p < 0.001). Throughout the course of the illness, 17.2% (47/274) adults with AQP4 antibodies had APS in distinction to 1.9% (2/107) adults with MOG antibodies with APS (p < 0.001).
Description: Quantitativesandwich ELISA kit for measuring Human Resistin in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.
Description: Quantitativesandwich ELISA kit for measuring Human Resistin in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.
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Conclusions: APS, one of many core scientific traits of people with AQP4 antibodies, is an especially uncommon manifestation in Korean adults with MOG antibodies.
