Beyond Antibodies: The DARPin Platform

The DARPin drug platform was established with a imaginative and prescient to develop the medical use of biologics past what was doable with monoclonal antibodies. It’s based mostly on naturally occurring ankyrin repeat domains which might be usually constructing blocks of multifunctional human proteins.

 

The platform permits for the era of various, well-behaved, multifunctional drug candidates. Current scientific knowledge illustrate the favorable security profile of the primary DARPin® molecules examined in sufferers. With the optimistic part III outcomes of essentially the most superior DARPin® drug candidate, abicipar, the DARPin® drug platform is doubtlessly about to realize its first advertising and marketing approval.

               

Genscanner
Genscanner

                     
This assessment highlights a few of the key milestones and selections encountered when reworking the DARPin® platform from an educational idea to a biotech drug pipeline engine.

Coexisting TIF1γ-positive Main Pulmonary Lymphoepithelioma-like Carcinoma and Anti-TIF1γ Antibody-positive Dermatomyositis: A Case Report

                     

Anti-transcriptional middleman issue 1γ (anti-TIF1γ) antibody-positive dermatomyositis (DM) is strongly related to most cancers, though the mechanism of motion continues to be unclear. We herein describe the primary recognized case of an 80-year-old lady recognized with TIF1γ-positive main pulmonary lymphoepithelioma-like carcinoma (LELC) coexisting with anti-TIF1γ antibody-positive DM.

Human Renal Tumor Antigen (RAGE) ELISA Kit

RDR-RAGE-Hu-48Tests 48 Tests
EUR 445.2

Human Renal Tumor Antigen (RAGE) ELISA Kit

RDR-RAGE-Hu-96Tests 96 Tests
EUR 610.8

anti-RAGE

YF-PA10116 50 ul
EUR 435.6
Description: Mouse polyclonal to RAGE

Anti-RAGE Antibody

A1706-100
EUR 574.8

Anti-RAGE antibody

STJ95358 200 µl
EUR 236.4
Description: Rabbit polyclonal to RAGE.

Anti-RAGE antibody

STJ95359 200 µl
EUR 236.4
Description: Rabbit polyclonal to RAGE.

Anti-RAGE (1C1)

YF-MA10022 100 ug
EUR 435.6
Description: Mouse monoclonal to RAGE

Anti-RAGE (1C1)

YF-MA11844 200 ul
EUR 435.6
Description: Mouse monoclonal to RAGE

Anti-RAGE (1C1)

YF-MA11845 200 ul
EUR 435.6
Description: Mouse monoclonal to RAGE

Anti-RAGE (1C1)

YF-MA11846 50 ug
EUR 435.6
Description: Mouse monoclonal to RAGE

Anti-RAGE (1D1)

YF-MA11847 100 ug
EUR 435.6
Description: Mouse monoclonal to RAGE

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 418.8

Anti Human RAGE Polyclonal Antibody

KH039
EUR 778.8
Description: The Anti Human RAGE Polyclonal Antibody is available in Europe and for worldwide shipping via Gentaur.

Anti-RAGE/AGER Antibody

PA1069 100ug/vial
EUR 400.8

Anti-RAGE/AGER Antibody

PB9469 100ug/vial
EUR 400.8

Goat Anti Human Rage Polyclonal Antibody

CPBT-66799GH 0.1 ml
EUR 858

RAGE

MO15029 500 ug
EUR 1092

RAGE

GT15030 100 ug
EUR 631.2

RAGE, human recombinant

4271-10
EUR 222

RAGE, human recombinant

4271-1000
EUR 5018.4

RAGE, human recombinant

4271-50
EUR 510

Anti-RAGE Rabbit Monoclonal Antibody

M03438 100ug/vial
EUR 476.4
Description: Rabbit Monoclonal RAGE Antibody. Validated in WB and tested in Human, Mouse, Rat.

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 336

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 336

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 336

RAGE antibody

70R-4337 50 ug
EUR 560.4
Description: Rabbit polyclonal RAGE antibody raised against the N terminal of RAGE

RAGE antibody

70R-1663 100 ug
EUR 452.4
Description: Rabbit polyclonal AGER antibody raised against the C terminal of AGER

RAGE antibody

70R-15273 100 ug
EUR 392.4
Description: Rabbit polyclonal RAGE antibody

RAGE antibody

70R-13753 100 ug
EUR 366
Description: Affinity purified Goat polyclonal RAGE antibody

RAGE antibody

38298-100ul 100ul
EUR 302.4

RAGE Antibody

49341-100ul 100ul
EUR 399.6

RAGE Antibody

49341-50ul 50ul
EUR 286.8

RAGE antibody

20R-RG001 250 ul
EUR 418.8
Description: Goat polyclonal RAGE antibody

RAGE antibody

20R-RG002 250 ul
EUR 484.8
Description: Goat polyclonal RAGE antibody

RAGE antibody

20R-RR001 100 ug
EUR 807.6
Description: Rabbit polyclonal RAGE antibody

RAGE Antibody

29058-100ul 100ul
EUR 302.4

RAGE Antibody

ABD6618 100 ug
EUR 525.6

RAGE antibody

70R-RG006 100 ug
EUR 360
Description: Affinity purified Goat polyclonal RAGE antibody

RAGE antibody

70R-RG007 100 ug
EUR 360
Description: Affinity purified Goat polyclonal RAGE antibody

RAGE antibody

70R-9435 50 ug
EUR 560.4
Description: Affinity purified rabbit polyclonal RAGE antibody

RAGE antibody

70R-5975 50 ug
EUR 560.4
Description: Rabbit polyclonal AGER antibody raised against the N terminal of AGER

RAGE antibody

70R-5978 50 ug
EUR 560.4
Description: Rabbit polyclonal AGER antibody raised against the C terminal of AGER

Human RAGE ELISA Kit

55R-1764 1 kit
EUR 805.2
Description: ELISA kit for detection of RAGE in the research laboratory

Human RAGE ELISA Kit

EHR0356 96Tests
EUR 625.2

Human Rage ELISA kit

LF-EK50731 1×96T
EUR 790.8

Antibody for Human RAGE

SPC-1292D 0.1ml
EUR 376.8
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is unconjugated.

Antibody for Human RAGE

SPC-1292D-A390 0.1ml
EUR 433.2
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 390.

Antibody for Human RAGE

SPC-1292D-A488 0.1ml
EUR 432
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 488.

Antibody for Human RAGE

SPC-1292D-A565 0.1ml
EUR 432
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 565.

Antibody for Human RAGE

SPC-1292D-A594 0.1ml
EUR 432
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 594.

Antibody for Human RAGE

SPC-1292D-A633 0.1ml
EUR 432
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 633.

Antibody for Human RAGE

SPC-1292D-A655 0.1ml
EUR 432
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 655.

Antibody for Human RAGE

SPC-1292D-A680 0.1ml
EUR 432
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 680.

Antibody for Human RAGE

SPC-1292D-A700 0.1ml
EUR 432
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to ATTO 700.

Antibody for Human RAGE

SPC-1292D-ALP 0.1ml
EUR 426
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Alkaline Phosphatase.

Antibody for Human RAGE

SPC-1292D-APC 0.1ml
EUR 430.8
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to APC .

Antibody for Human RAGE

SPC-1292D-APCCY7 0.1ml
EUR 518.4
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to APC/Cy7.

Antibody for Human RAGE

SPC-1292D-BI 0.1ml
EUR 428.4
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Biotin.

Antibody for Human RAGE

SPC-1292D-DY350 0.1ml
EUR 523.2
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Dylight 350.

Antibody for Human RAGE

SPC-1292D-DY405 0.1ml
EUR 494.4
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Dylight 405.

Antibody for Human RAGE

SPC-1292D-DY488 0.1ml
EUR 471.6
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Dylight 488.

Antibody for Human RAGE

SPC-1292D-DY594 0.1ml
EUR 476.4
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Dylight 594.

Antibody for Human RAGE

SPC-1292D-DY633 0.1ml
EUR 464.4
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Dylight 633.

Antibody for Human RAGE

SPC-1292D-FITC 0.1ml
EUR 423.6
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to FITC.

Antibody for Human RAGE

SPC-1292D-HRP 0.1ml
EUR 418.8
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to HRP.

Antibody for Human RAGE

SPC-1292D-P594 0.1ml
EUR 440.4
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to PE/ATTO 594.

Antibody for Human RAGE

SPC-1292D-PCP 0.1ml
EUR 430.8
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to PerCP.

Antibody for Human RAGE

SPC-1292D-RPE 0.1ml
EUR 429.6
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to RPE .

Antibody for Human RAGE

SPC-1292D-STR 0.1ml
EUR 430.8
Description: A polyclonal antibody for RAGE from Human. The antibody is produced in rabbit after immunization with Human A synthesized peptide derived from human RAGE. The Antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000), IHC (1:200). This RAGE antibody is conjugated to Streptavidin.

Anti Human RAGE Monoclonal Antibody (Clone No. 1C5)

KG134
EUR 856.8
Description: The Anti Human RAGE Monoclonal Antibody (Clone No. 1C5) is available in Europe and for worldwide shipping via Gentaur.

RAGE antibody (HRP)

60R-1657 100 ug
EUR 392.4
Description: Rabbit polyclonal RAGE antibody (HRP)

RAGE antibody (FITC)

60R-1658 100 ug
EUR 392.4
Description: Rabbit polyclonal RAGE antibody (FITC)

RAGE antibody (biotin)

60R-1659 100 ug
EUR 392.4
Description: Rabbit polyclonal RAGE antibody (biotin)

RAGE Polyclonal Antibody

41387-100ul 100ul
EUR 302.4

RAGE Polyclonal Antibody

41387-50ul 50ul
EUR 224.4

RAGE Blocking Peptide

33R-2976 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of AGER antibody, catalog no. 70R-5975

RAGE Blocking Peptide

33R-7361 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of AGER antibody, catalog no. 70R-5978

                       

The prognosis of LELC can solely be made by a surgical lung biopsy, and never by a computed tomography-guided biopsy, due to heavy lymphocytic infiltration. This instructive case reaffirmed the significance of energetic screening for malignancy in sufferers with anti-TIF1γ antibody-positive DM.

                       

Curiously, the outcomes additionally advised that the robust relationship which exists between anti-TIF1γ antibody-positive DM and most cancers is doubtlessly attributable to tumor-derived TIF1γ.

                       

Worth of Space Postrema Syndrome in Differentiating Adults With AQP4 vs. MOG Antibodies

Targets: To match the frequency of space postrema syndrome (APS) in adults with anti-aquaporin-4 (AQP4) and anti-myelin oligodendrocyte glycoprotein (MOG) antibodies.

                       

Strategies: APS is outlined as acute or subacute, single or mixed, episodic or fixed nausea, vomiting, or hiccups, persisting for not less than 48 h, which can’t be attributed to some other etiology. The presence of APS was investigated in 274 adults with AQP4 antibodies and 107 adults with MOG antibodies from 10 hospitals. ‘

                       

Outcomes: The research inhabitants comprised Korean adults (≥18 years). On the time of illness onset, 14.9% (41/274) adults with AQP4 antibodies had APS, whereas not one of the individuals with MOG antibodies developed APS (p < 0.001). Throughout the course of the illness, 17.2% (47/274) adults with AQP4 antibodies had APS in distinction to 1.9% (2/107) adults with MOG antibodies with APS (p < 0.001).

                       

Anti-Resistin (5E8)

YF-MA18968 100 ug
EUR 435.6
Description: Mouse monoclonal to Resistin

Anti-Resistin (4B11)

YF-MA18969 200 ul
EUR 435.6
Description: Mouse monoclonal to Resistin

Anti-Resistin (2H8)

YF-MA18970 100 ug
EUR 435.6
Description: Mouse monoclonal to Resistin

Anti-Resistin (4C8)

YF-MA18971 100 ug
EUR 435.6
Description: Mouse monoclonal to Resistin

Anti-Resistin (6H8)

YF-MA18972 100 ug
EUR 435.6
Description: Mouse monoclonal to Resistin

Anti-Resistin (4H8)

YF-MA18973 100 ug
EUR 435.6
Description: Mouse monoclonal to Resistin

Anti-Resistin (6C3)

YF-MA18974 100 ug
EUR 435.6
Description: Mouse monoclonal to Resistin

Anti-Resistin/RETN Antibody

PA1473 100ug/vial
EUR 400.8

Anti-Resistin/RETN Antibody

PB9412 100ug/vial
EUR 352.8

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 336

                      

Conclusions: APS, one of many core scientific traits of people with AQP4 antibodies, is an especially uncommon manifestation in Korean adults with MOG antibodies.