We report right here on HIV-1 immunization leads to rabbits and macaques co-immunized with clade C gp160 DNA and gp140 trimeric envelope vaccines, a method just like a latest medical trial that confirmed improved pace and magnitude of humoral responses.
Clade C envelopes had been remoted from CAP257, a person who developed a novel temporal sample of neutralization breadth improvement, comprising three separate “Waves” focusing on distinct Env epitopes and completely different HIV clades. We used phylogeny and neutralization standards to down-select envelope vaccine candidates, and confirmed antigenicity of our antigens by interplay with well-characterized broadly neutralizing monoclonal antibodies. Utilizing these envelopes, we carried out rabbit research that screened for immunogenicity of CAP257 Envs from timepoints previous peak neutralization breadth in every Wave. Chosen CAP257 envelopes from Waves 1 and a pair of, in the course of the first 2 years of an infection that had been extremely immunogenic in rabbits had been then examined in macaques.
We discovered that in rabbits and macaques, co-immunization of DNA, and protein envelope-based vaccines induced most binding and neutralizing antibody titers with three immunizations. No additional profit was obtained with extra immunizations. The vaccine methods recapitulated the Wave-specific epitope focusing on noticed within the CAP257 participant, and elicited Tier 1A, 1B, and Tier 2 heterologous neutralization. CAP257 envelope immunogens additionally induced the event of ADCC and TFH responses in macaques, and these responses positively correlated with heterologous neutralization.
Collectively, the outcomes from two animal fashions on this research have implications for figuring out efficient vaccine immunogens. We used a multi-step technique to (1) choose an Env donor with well-characterized neutralization breadth improvement; (2) research Env phylogeny for potential immunogens circulating close to peak breadth timepoints in the course of the first 2 years of an infection; (3) check down-selected Envs for antigenicity; (4) display down-selected Envs in an efficient vaccine routine in rabbits; and (5) advance essentially the most immunogenic Envs to NHP research.
 PSMB9 antibody |
|
70R-5740 |
Fitzgerald |
50 ug |
EUR 560.4 |
|
Description: Rabbit polyclonal PSMB9 antibody raised against the C terminal of PSMB9 |
 PSMB9 Antibody |
|
32427-100ul |
SAB |
100ul |
EUR 302.4 |
PSMB9 antibody |
|
10R-7115 |
Fitzgerald |
100 ul |
EUR 829.2 |
|
Description: Mouse monoclonal PSMB9 antibody |
PSMB9 antibody |
|
10R-7116 |
Fitzgerald |
100 ul |
EUR 829.2 |
|
Description: Mouse monoclonal PSMB9 antibody |
PSMB9 antibody |
|
10R-7117 |
Fitzgerald |
100 ul |
EUR 829.2 |
|
Description: Mouse monoclonal PSMB9 antibody |
PSMB9 antibody |
|
10R-7119 |
Fitzgerald |
100 ul |
EUR 871.2 |
|
Description: Mouse monoclonal PSMB9 antibody |
PSMB9 antibody |
|
10R-7120 |
Fitzgerald |
100 ul |
EUR 829.2 |
|
Description: Mouse monoclonal PSMB9 antibody |
PSMB9 antibody |
|
10R-7122 |
Fitzgerald |
100 ul |
EUR 829.2 |
|
Description: Mouse monoclonal PSMB9 antibody |
 PSMB9 Conjugated Antibody |
|
C32427 |
SAB |
100ul |
EUR 476.4 |
 PSMB9 siRNA |
|
20-abx930158 |
Abbexa |
|
|
|
|
PSMB9 siRNA |
|
20-abx930159 |
Abbexa |
|
|
|
|
 PSMB9 Peptide |
|
42-661P |
ProSci |
0.1 mg |
EUR 405.6 |
|
Description: (IN) PSMB9 Peptide |
PSMB9 siRNA |
|
20-abx904318 |
Abbexa |
|
|
|
|
 PSMB9 Antibody, HRP conjugated |
|
1-CSB-PA018887LB01HU |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against PSMB9. Recognizes PSMB9 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
 PSMB9 Antibody, FITC conjugated |
|
1-CSB-PA018887LC01HU |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against PSMB9. Recognizes PSMB9 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
 PSMB9 Antibody, Biotin conjugated |
|
1-CSB-PA018887LD01HU |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against PSMB9. Recognizes PSMB9 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
 PSMB9 Blocking Peptide |
|
DF6606-BP |
Affbiotech |
1mg |
EUR 234 |
 PSMB9 cloning plasmid |
|
CSB-CL018887HU-10ug |
Cusabio |
10ug |
EUR 279.6 |
|
|
|
Description: A cloning plasmid for the PSMB9 gene. |
PSMB9 Blocking Peptide |
|
33R-8138 |
Fitzgerald |
100 ug |
EUR 216 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PSMB9 antibody, catalog no. 70R-5740 |
 PSMB9 Rabbit pAb |
|
A1771-100ul |
Abclonal |
100 ul |
EUR 369.6 |
PSMB9 Rabbit pAb |
|
A1771-200ul |
Abclonal |
200 ul |
EUR 550.8 |
PSMB9 Rabbit pAb |
|
A1771-20ul |
Abclonal |
20 ul |
EUR 219.6 |
PSMB9 Rabbit pAb |
|
A1771-50ul |
Abclonal |
50 ul |
EUR 267.6 |
 Polyclonal Goat anti-GST α-form |
|
GST-ANTI-1 |
Detroit R&D |
50 uL |
EUR 336 |
 Polyclonal Goat anti-GST μ-form |
|
GST-ANTI-2 |
Detroit R&D |
50 uL |
EUR 336 |
 Polyclonal Goat anti-GST p-form |
|
GST-ANTI-3 |
Detroit R&D |
50 uL |
EUR 336 |
) Polyclonal PSMB9 Antibody (C-term) |
|
APR06094G |
Leading Biology |
0.1ml |
EUR 580.8 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PSMB9 (C-term). This antibody is tested and proven to work in the following applications: |
Polyclonal PSMB9 Antibody (C-term) |
|
APR06933G |
Leading Biology |
0.1ml |
EUR 580.8 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PSMB9 (C-term). This antibody is tested and proven to work in the following applications: |
) Polyclonal PSMB9 Antibody (C-Term) |
|
APR04883G |
Leading Biology |
0.1ml |
EUR 580.8 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PSMB9 (C-Term). This antibody is tested and proven to work in the following applications: |
) Polyclonal PSMB9 Antibody (internal region) |
|
APG00705G |
Leading Biology |
0.1mg |
EUR 580.8 |
|
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human PSMB9 (internal region). This antibody is tested and proven to work in the following applications: |
 Rat PSMB9 shRNA Plasmid |
|
20-abx984733 |
Abbexa |
|
|
|
|
 Human PSMB9 shRNA Plasmid |
|
20-abx953845 |
Abbexa |
|
|
|
|
 Mouse PSMB9 shRNA Plasmid |
|
20-abx971336 |
Abbexa |
|
|
|
|
) PSMB9 protein (His tag) |
|
80R-1755 |
Fitzgerald |
50 ug |
EUR 366 |
|
Description: Purified recombinant Human PSMB9 protein |
) PSMB9 Recombinant Protein (Human) |
|
RP024946 |
ABM |
100 ug |
Ask for price |
) PSMB9 Recombinant Protein (Rat) |
|
RP222632 |
ABM |
100 ug |
Ask for price |
) PSMB9 Recombinant Protein (Mouse) |
|
RP165290 |
ABM |
100 ug |
Ask for price |
 Human LMP7/PSMB9 ELISA Kit |
|
EHL0251 |
Abclonal |
96Tests |
EUR 625.2 |
 Porcine LMP7/PSMB9 ELISA Kit |
|
EPL0251 |
Abclonal |
96Tests |
EUR 625.2 |
 Mouse LMP7/PSMB9 ELISA Kit |
|
EML0251 |
Abclonal |
96Tests |
EUR 625.2 |
 Rat LMP7/PSMB9 ELISA Kit |
|
ERL0251 |
Abclonal |
96Tests |
EUR 625.2 |
 Rabbit LMP7/PSMB9 ELISA Kit |
|
ERTL0251 |
Abclonal |
96Tests |
EUR 625.2 |
 (OKAN06594)) PSMB9 ELISA Kit (Human) (OKAN06594) |
|
OKAN06594 |
Aviva Systems Biology |
96 Wells |
EUR 950.4 |
|
Description: Description of target: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.057 ng/mL |
 (OKCD06246)) PSMB9 ELISA Kit (Human) (OKCD06246) |
|
OKCD06246 |
Aviva Systems Biology |
96 Wells |
EUR 903.6 |
|
Description: Description of target: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMB9 is a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This subunit is involved in antigen processing to generate class I binding peptides. Expression of PSMB9 is induced by gamma interferon and it replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding different isoforms have been identified; both isoforms are processed to yield the same mature subunit.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.057ng/mL |
 (OKEH04653)) PSMB9 ELISA Kit (Human) (OKEH04653) |
|
OKEH04653 |
Aviva Systems Biology |
96 Wells |
EUR 794.4 |
|
Description: Description of target: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.067 ng/mL |
 (OKEH04654)) Psmb9 ELISA Kit (Mouse) (OKEH04654) |
|
OKEH04654 |
Aviva Systems Biology |
96 Wells |
EUR 794.4 |
|
Description: Description of target: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Contributes to NFKBIA degradation and subsequently NFKB1 generation.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.165 ng/mL |
 (OKEH04655)) Psmb9 ELISA Kit (Rat) (OKEH04655) |
|
OKEH04655 |
Aviva Systems Biology |
96 Wells |
EUR 794.4 |
|
Description: Description of target: Subunit of the proteasome complex, which may play a role in protein catabolism.;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.166 ng/mL |
 (pORF)) Psmb9 ORF Vector (Rat) (pORF) |
|
ORF074212 |
ABM |
1.0 ug DNA |
EUR 607.2 |
 (pORF)) PSMB9 ORF Vector (Human) (pORF) |
|
ORF008316 |
ABM |
1.0 ug DNA |
EUR 114 |
 (pORF)) Psmb9 ORF Vector (Mouse) (pORF) |
|
ORF055098 |
ABM |
1.0 ug DNA |
EUR 607.2 |
 Goat LMP7/PSMB9 ELISA Kit |
|
EGTL0251 |
Abclonal |
96Tests |
EUR 625.2 |
The outcomes had been an induction of excessive titers of HIV-1 envelope-specific antibodies with rising avidity and cross-clade neutralizing antibodies with effector features that collectively might enhance the potential for defense in a pre-clinical SHIV mannequin.
Key phrases: ADCC; HIV vaccine; NHP; TFH responses; co-immunization; envelope immunogen; neutralizing antibodies; rabbit.
Synergistic antitumor exercise of a DLL4/VEGF bispecific therapeutic antibody together with irinotecan in gastric most cancers
 PSMB8 Antibody |
|
1-CSB-PA775839 |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
PSMB8 Antibody |
|
1-CSB-PA116429 |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
PSMB8 Antibody |
|
1-CSB-PA018886GA01HU |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF |
PSMB8 Antibody |
|
1-CSB-PA018886LA01HU |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200 |
 PSMB8 Conjugated Antibody |
|
C43134 |
SAB |
100ul |
EUR 476.4 |
 Anti-PSMB8 antibody |
|
STJ11100809 |
St John's Laboratory |
100 µl |
EUR 495.6 |
|
Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. |
Anti-PSMB8 antibody |
|
STJ29479 |
St John's Laboratory |
100 µl |
EUR 332.4 |
|
Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. |
 PSMB8 Polyclonal Antibody |
|
A73468-050 |
EpiGentek |
50 ul |
EUR 377.3 |
PSMB8 Polyclonal Antibody |
|
A73468-100 |
EpiGentek |
100 ul |
EUR 577.5 |
 PSMB8 siRNA |
|
20-abx904317 |
Abbexa |
|
|
|
|
PSMB8 siRNA |
|
20-abx930156 |
Abbexa |
|
|
|
|
PSMB8 siRNA |
|
20-abx930157 |
Abbexa |
|
|
|
|
 PSMB8 Antibody, HRP conjugated |
|
1-CSB-PA018886LB01HU |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
 PSMB8 Antibody, FITC conjugated |
|
1-CSB-PA018886LC01HU |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
 PSMB8 Antibody, Biotin conjugated |
|
1-CSB-PA018886LD01HU |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
 PSMB8 Rabbit pAb |
|
A7340-100ul |
Abclonal |
100 ul |
EUR 369.6 |
PSMB8 Rabbit pAb |
|
A7340-200ul |
Abclonal |
200 ul |
EUR 550.8 |
PSMB8 Rabbit pAb |
|
A7340-20ul |
Abclonal |
20 ul |
EUR 219.6 |
PSMB8 Rabbit pAb |
|
A7340-50ul |
Abclonal |
50 ul |
EUR 267.6 |
 PSMB8 Blocking Peptide |
|
BF0434-BP |
Affbiotech |
1mg |
EUR 234 |
) anti-PSMB8 (1A5) |
|
LF-MA30618 |
Abfrontier |
100 ul |
EUR 632.4 |
|
Description: Mouse Monoclonal to PSMB8 |
 Monoclonal PSMB8 Antibody, Clone: 1A5 |
|
AMM02864G |
Leading Biology |
0.1ml |
EUR 633.6 |
|
Description: A Monoclonal antibody against Human PSMB8. The antibodies are raised in Mouse and are from clone 1A5. This antibody is applicable in WB and IHC, ICC, E |
 Anti-PSMB8 / LMP7 Monoclonal Antibody |
|
M02188-2 |
BosterBio |
100ug |
EUR 476.4 |
|
Description: Rabbit Monoclonal PSMB8 / LMP7 Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat. |
) PSMB8 protein (His tag) |
|
80R-2608 |
Fitzgerald |
100 ug |
EUR 386.4 |
|
Description: Purified recombinant PSMB8 protein |
 Human PSMB8 shRNA Plasmid |
|
20-abx953843 |
Abbexa |
|
|
|
|
 Rat PSMB8 shRNA Plasmid |
|
20-abx984734 |
Abbexa |
|
|
|
|
 Mouse PSMB8 shRNA Plasmid |
|
20-abx971337 |
Abbexa |
|
|
|
|
) PSMB8 Recombinant Protein (Rat) |
|
RP222629 |
ABM |
100 ug |
Ask for price |
) PSMB8 Recombinant Protein (Human) |
|
RP085356 |
ABM |
100 ug |
Ask for price |
) PSMB8 Recombinant Protein (Mouse) |
|
RP165287 |
ABM |
100 ug |
Ask for price |
 Antibody) Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
|
20-abx141396 |
Abbexa |
-
EUR 444.00
-
EUR 727.20
-
EUR 360.00
|
|
|
|
Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
|
20-abx006453 |
Abbexa |
-
EUR 493.20
-
EUR 710.40
-
EUR 218.40
-
EUR 376.80
|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
|
|
Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
|
20-abx114776 |
Abbexa |
|
|
|
|
Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
|
abx011689-100ul |
Abbexa |
100 ul |
EUR 493.2 |
|
|
Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
|
abx028154-400ul |
Abbexa |
400 ul |
EUR 627.6 |
|
|
Proteasome Subunit Beta Type-8 (PSMB8) Antibody |
|
abx028154-80l |
Abbexa |
80 µl |
EUR 343.2 |
|
|
 Antibody) Proteasome subunit beta type-8 (PSMB8) Antibody |
|
20-abx211178 |
Abbexa |
|
|
|
|
Proteasome subunit beta type-8 (PSMB8) Antibody |
|
20-abx211851 |
Abbexa |
|
|
|
|
 (M01), Clone: 1B3) Monoclonal PSMB8 Antibody (monoclonal) (M01), Clone: 1B3 |
|
AMM03954G |
Leading Biology |
0.1mg |
EUR 580.8 |
|
Description: A Monoclonal antibody against Human PSMB8 (monoclonal) (M01). The antibodies are raised in Mouse and are from clone 1B3. This antibody is applicable in WB, IHC and IF, IP, E |
 [KO Validated] PSMB8 Rabbit pAb |
|
A19933-100ul |
Abclonal |
100 ul |
EUR 492 |
[KO Validated] PSMB8 Rabbit pAb |
|
A19933-200ul |
Abclonal |
200 ul |
EUR 685.2 |
[KO Validated] PSMB8 Rabbit pAb |
|
A19933-20ul |
Abclonal |
20 ul |
EUR 265.2 |
[KO Validated] PSMB8 Rabbit pAb |
|
A19933-50ul |
Abclonal |
50 ul |
EUR 344.4 |
 (OKEH07770)) PSMB8 ELISA Kit (Human) (OKEH07770) |
|
OKEH07770 |
Aviva Systems Biology |
96 Wells |
EUR 1310.4 |
|
Description: Description of target: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.06ng/mL |
 (pORF)) Psmb8 ORF Vector (Mouse) (pORF) |
|
ORF055097 |
ABM |
1.0 ug DNA |
EUR 607.2 |
 (pORF)) Psmb8 ORF Vector (Rat) (pORF) |
|
ORF074211 |
ABM |
1.0 ug DNA |
EUR 607.2 |
 (OKEH03975)) PSMB8 ELISA Kit (Dog) (OKEH03975) |
|
OKEH03975 |
Aviva Systems Biology |
96 Wells |
EUR 1012.8 |
|
Description: Description of target: ;Species reactivity: Dog;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.064 ng/mL |
 (OKCD02695)) PSMB8 ELISA Kit (Human) (OKCD02695) |
|
OKCD02695 |
Aviva Systems Biology |
96 Wells |
EUR 950.4 |
|
Description: Description of target: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.117 ng/mL |
 (pORF)) PSMB8 ORF Vector (Human) (pORF) |
|
ORF028453 |
ABM |
1.0 ug DNA |
EUR 486 |
) Psmb8 sgRNA CRISPR Lentivector set (Rat) |
|
K6921501 |
ABM |
3 x 1.0 ug |
EUR 406.8 |
) PSMB8 sgRNA CRISPR Lentivector set (Human) |
|
K1740301 |
ABM |
3 x 1.0 ug |
EUR 406.8 |
) Psmb8 sgRNA CRISPR Lentivector set (Mouse) |
|
K4425601 |
ABM |
3 x 1.0 ug |
EUR 406.8 |
) Human Proteasome subunit beta type-8 (PSMB8) |
|
1-CSB-EP018886HU |
Cusabio |
-
EUR 456.00
-
EUR 256.80
-
EUR 1570.80
-
EUR 672.00
-
EUR 1047.60
-
EUR 314.40
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
|
|
Description: Recombinant Human Proteasome subunit beta type-8(PSMB8) expressed in E.coli |
 (Target 1)) Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 1) |
|
K6921502 |
ABM |
1.0 ug DNA |
EUR 184.8 |
 (Target 2)) Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 2) |
|
K6921503 |
ABM |
1.0 ug DNA |
EUR 184.8 |
 (Target 3)) Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 3) |
|
K6921504 |
ABM |
1.0 ug DNA |
EUR 184.8 |
 (Target 1)) PSMB8 sgRNA CRISPR Lentivector (Human) (Target 1) |
|
K1740302 |
ABM |
1.0 ug DNA |
EUR 184.8 |
 (Target 2)) PSMB8 sgRNA CRISPR Lentivector (Human) (Target 2) |
|
K1740303 |
ABM |
1.0 ug DNA |
EUR 184.8 |
 (Target 3)) PSMB8 sgRNA CRISPR Lentivector (Human) (Target 3) |
|
K1740304 |
ABM |
1.0 ug DNA |
EUR 184.8 |
 (Target 1)) Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 1) |
|
K4425602 |
ABM |
1.0 ug DNA |
EUR 184.8 |
 (Target 2)) Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 2) |
|
K4425603 |
ABM |
1.0 ug DNA |
EUR 184.8 |
 (Target 3)) Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 3) |
|
K4425604 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Notch signaling has been recognized as a vital pathway in gastric most cancers (GC) development and metastasis, and inhibition of Delta-like ligand 4 (DLL4), a Notch ligand, is usually recommended as a potent therapeutic strategy for GC. Expression of each DLL4 and vascular endothelial development issue receptor 2 (VEGFR2) was related within the malignant tissues of GC sufferers.
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- We centered on vascular endothelial development issue (VEGF), a recognized angiogenesis regulator and activator of DLL4. Right here, we used ABL001, a DLL4/VEGF bispecific therapeutic antibody, and investigated its therapeutic impact in GC.
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- Remedy with human DLL4 therapeutic antibody (anti-hDLL4) or ABL001 barely diminished GC cell development in monolayer tradition; nonetheless, they considerably inhibited cell development in 3D-culture, suggesting a discount within the most cancers stem cell inhabitants. Remedy with anti-hDLL4 or ABL001 additionally decreased GC cell migration and invasion.
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- Furthermore, the mixed therapy of irinotecan with anti-hDLL4 or ABL001 confirmed synergistic antitumor exercise. Each mixture remedies additional diminished cell development in 3D-culture in addition to cell invasion. Apparently, the mix therapy of ABL001 with irinotecan synergistically diminished the GC burden in each xenograft and orthotopic mouse fashions.
- Collectively, DLL4 inhibition considerably decreased cell motility and stem-like phenotype and the mix therapy of DLL4/VEGF bispecific therapeutic antibody with irinotecan synergistically diminished the GC burden in mouse fashions. Our information recommend that ABL001 doubtlessly represents a potent agent in GC remedy. Additional biochemical and pre-clinical research are wanted for its software within the clinic.
