SARS-CoV-2 specific neutralising antibodies in blood donors

We evaluated SARS-CoV-2 RNA and neutralising antibodies in blood donors (BD) residing within the Lodi Purple Zone, Italy. Of 390 BDs recruited after 20 February 2020 – when the primary COVID-19 case in Lombardy was recognized, 91 (23%) aged 19-70 years had been antibody constructive.

                     
                     

Viral RNA was detected in an extra 17 (4.3%) BDs, yielding ca 28% (108/390) with proof of virus publicity. 5 saved samples collected as early as 12 February had been seropositive.

                     
                     

Key phrases: Lodi Purple Zone; SARS-CoV-2 seroprevalence; epidemiology; microneutralization assay.

                     
                     

                                           

NMDAR Antibodies Alter Dopamine Receptors and Trigger Psychotic Conduct in Mice

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Goal: The goal was to exhibit that antibodies from sufferers with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis alter the degrees of dopamine 1 receptor (D1R) and dopamine 2 receptor (D2R) and trigger psychotic-like options in mice.

                     
                     

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

AP76216 1mg
EUR 2649

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-10ug 10ug
EUR 151.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-1mg 1mg
EUR 2252.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-500ug 500ug
EUR 1593.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-50ug 50ug
EUR 278.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

AP76176 1mg
EUR 2369

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

AP76258 1mg
EUR 2649

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-10ug 10ug
EUR 151.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-1mg 1mg
EUR 2252.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-500ug 500ug
EUR 1593.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-50ug 50ug
EUR 278.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-10ug 10ug
EUR 132
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-1mg 1mg
EUR 2008.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-500ug 500ug
EUR 1423.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-50ug 50ug
EUR 278.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (RPE)

abx415214-100tests 100 tests
EUR 710.4

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (FITC)

abx415212-01mg 0.1 mg
EUR 610.8

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody

32146-05111 150 ug
EUR 215

Anti-Mouse T-cell Immunoglobulin Mucin-1 (TIM-1) Antibody

103-M274 100 µg
EUR 399
Description: MUC-1 (Mucin-1; also PEM, PEMT, Episialin, tumor-associated mucin, and carcinoma associated mucin) is a 240-450 kDa type I transmembrane glycoprotein. Human MUC-1 is 1255 amino acids (aa) in length and contains a 23 aa signal sequence, a 1135 aa extracellular domain (ECD), a 23 aa transmembrane segment, and a 74 aa cytoplasmic tail. The ECD consists of degenerate tandem repeats and a tandem repeat region, which makes up the major portion of the protein. Potential O-glycosylation sites (serines and threonines) make up more than one-fourth of the amino acids. Splicing variants produce ten isoforms for human MUC-1. Human MUC-1 is 28% aa identical to mouse MUC-1.

Anti-Mouse T-cell Immunoglobulin Mucin-2 (TIM-2) Antibody

103-M275 100 µg
EUR 399
Description: TIM-2 is a type I membrane protein and is a member of the TIM protein family. TIM-2 has an immunoglobulin variable region-like domain followed by a mucin-like domain in its extracellular region.This protein family is characterized by their conserved immunoglobulin and mucin domains, as well as by their expression on activated T cells. TIM-2 is a receptor for Semaphorin 4A, which is expressed on dendritic cells and B cells. Semaphorin 4A has been shown to enhance T cell activation.

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (AP)

MBS6248357-01mL 0.1(mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (AP)

MBS6248357-5x01mL 5x0.1mL
EUR 3720

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (PE)

MBS6252228-01mL 0.1(mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (PE)

MBS6252228-5x01mL 5x0.1mL
EUR 3720

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (HRP)

MBS6251292-01mL 0.1(mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (HRP)

MBS6251292-5x01mL 5x0.1mL
EUR 3720

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (APC)

MBS6269209-01mL 0.1mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (APC)

MBS6269209-5x01mL 5x0.1mL
EUR 3720

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (FITC)

MBS6250265-01mL 0.1(mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (FITC)

MBS6250265-5x01mL 5x0.1mL
EUR 3720

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (Biotin)

MBS6249365-01mL 0.1(mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (Biotin)

MBS6249365-5x01mL 5x0.1mL
EUR 3720

Human T Lymphocyte Immunoglobulin mucin 3,TIM-3 ELISA KIT

E7264Hu-1096T 10*96T
EUR 4122

Human T Lymphocyte Immunoglobulin mucin 3,TIM-3 ELISA KIT

E7264Hu-48wells 48 wells
EUR 300

Human T Lymphocyte Immunoglobulin mucin 3,TIM-3 ELISA KIT

E7264Hu-596T 5*96T
EUR 2061

Human T Lymphocyte Immunoglobulin mucin 3,TIM-3 ELISA KIT

E7264Hu-96wells 96 wells
EUR 458

Human T Lymphocyte Immunoglobulin mucin 3, TIM-3 ELISA Kit

MBS1608155-10x96StripWells 10x96-Strip-Wells
EUR 3460

Human T Lymphocyte Immunoglobulin mucin 3, TIM-3 ELISA Kit

MBS1608155-48StripWells 48-Strip-Wells
EUR 285

Human T Lymphocyte Immunoglobulin mucin 3, TIM-3 ELISA Kit

MBS1608155-5x96StripWells 5x96-Strip-Wells
EUR 1750

Human T Lymphocyte Immunoglobulin mucin 3, TIM-3 ELISA Kit

MBS1608155-96StripWells 96-Strip-Wells
EUR 425

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 490)

MBS6254307-01mL 0.1(mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 490)

MBS6254307-5x01mL 5x0.1mL
EUR 3720

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 550)

MBS6255347-01mL 0.1(mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 550)

MBS6255347-5x01mL 5x0.1mL
EUR 3720

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 405)

MBS6253267-01mL 0.1(mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 405)

MBS6253267-5x01mL 5x0.1mL
EUR 3720

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 750)

MBS6257426-01mL 0.1mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 750)

MBS6257426-5x01mL 5x0.1mL
EUR 3720

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 650)

MBS6256387-01mL 0.1(mL
EUR 860

TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (MaxLight 650)

MBS6256387-5x01mL 5x0.1mL
EUR 3720

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (Biotin Conjugate)

32146-05121 150 ug
EUR 315

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (AP)

MBS6248356-01mL 0.1(mL
EUR 860

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (AP)

MBS6248356-5x01mL 5x0.1mL
EUR 3720

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (AP)

MBS6248358-01mL 0.1(mL
EUR 860

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (AP)

MBS6248358-5x01mL 5x0.1mL
EUR 3720

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (PE)

MBS6252227-01mL 0.1(mL
EUR 860

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (PE)

MBS6252227-5x01mL 5x0.1mL
EUR 3720

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (PE)

MBS6252229-01mL 0.1(mL
EUR 860

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (PE)

MBS6252229-5x01mL 5x0.1mL
EUR 3720

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (HRP)

MBS6251291-01mL 0.1(mL
EUR 860

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (HRP)

MBS6251291-5x01mL 5x0.1mL
EUR 3720

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (HRP)

MBS6251293-01mL 0.1(mL
EUR 860

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (HRP)

MBS6251293-5x01mL 5x0.1mL
EUR 3720

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (APC)

MBS6269208-01mL 0.1mL
EUR 860

TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (APC)

MBS6269208-5x01mL 5x0.1mL
EUR 3720

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (APC)

MBS6269210-5x01mL 5x0.1mL
EUR 3720

TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (APC)

MBS6269210-01mL 0.1mL
EUR 860

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx411874-01mg 0.1 mg
EUR 644.4

T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody

abx411875-01mg 0.1 mg
EUR 661.2

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx415204-05mg 0.5 mg
EUR 994.8

                     

Strategies: Cultured rat hippocampal neurons had been handled with cerebrospinal fluid (CSF) from sufferers with anti-NMDAR encephalitis or controls, and the consequences on clusters of D1R and D2R had been quantified. In vivo research included 71 C57BL/6J mice that had been chronically infused with CSF from sufferers or controls by way of ventricular catheters linked to subcutaneous osmotic pumps.

                     

Prepulse inhibition of the acoustic startling reflex (PPI; a marker of psychotic-like habits), reminiscence, locomotor exercise, and the density of cell-surface and synaptic D1R, D2R, and NMDAR clusters had been examined at completely different time factors utilizing reported strategies.

                     

Outcomes: In cultured neurons, CSF from sufferers, however not from controls, brought about a major lower of cell-surface D1R and a rise of D2R clusters. In mice, CSF from sufferers brought about a major lower of synaptic and complete cell-surface D1R clusters and a rise of D2R clusters related to a lower of PPI.

                     

These results had been accompanied by reminiscence impairment and a discount of floor NMDARs, as reported on this mannequin. The psychotic-like options, reminiscence impairment, and modifications in ranges of D1R, D2R, and NMDAR progressively improved a number of days after the infusion of CSF from sufferers stopped.

                     

Interpretation: Along with reminiscence deficits and discount of NMDARs, CSF antibodies from sufferers with anti-NMDAR encephalitis trigger reversible psychotic-like options accompanied by modifications (D1R lower, D2R enhance) in cell-surface dopamine receptor clusters. ANN NEUROL 2020.

                     

Complement activation by human IgG antibodies to galactose-α-1,3-galactose

                       

Some human antibodies might paradoxically inhibit complement activation on micro organism and improve pathogen survival in people. This property was additionally claimed for IgG antibodies reacting with terminal galactose-α-1,3-galactose (Galα3Gal; IgG anti-αGal), a naturally occurring and considerable antibody in human plasma that targets quite a few completely different pathogens.                      

  • To reinvestigate these results, we used IgG anti-αGal affinity remoted from a pool of regular human IgG and human hypogammaglobulinaemia serum as a complement supply.
  •                

 

  • Move cytometry was carried out to look at antibody binding and complement deposition on pig erythrocytes, Escherichia coli O86 and Streptococcus pneumoniae serotype 9V.
  •                

 

  • Particular nanobodies had been used to dam the impact of single complement components and to delineate the complement pathways concerned.
  •                  

                     

IgG anti-αGal was able to activating the classical complement pathway on all of the examined goal cells. The diploma of activation was exponentially associated to the density of sure antibody on E. coli O86 and pig erythrocytes, however extra linearly on S. pneumoniae 9V.                      

 

Human Leukotriene E4 ELISA kit

E01A5638 96T
EUR 700
Description: ELISA

Human Leukotriene A4 ELISA kit

E01L0035-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Leukotriene A4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Leukotriene A4 ELISA kit

E01L0035-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Leukotriene A4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Leukotriene A4 ELISA kit

E01L0035-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Leukotriene A4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Leukotriene C4 ELISA kit

E01L0036-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Leukotriene C4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Leukotriene C4 ELISA kit

E01L0036-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Leukotriene C4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Leukotriene C4 ELISA kit

E01L0036-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Leukotriene C4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Leukotriene B4 ELISA kit

E01L0037-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Leukotriene B4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Leukotriene B4 ELISA kit

E01L0037-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Leukotriene B4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Leukotriene B4 ELISA kit

E01L0037-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Leukotriene B4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Leukotriene D4 ELISA kit

E01L0287-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Leukotriene D4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Leukotriene D4 ELISA kit

E01L0287-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Leukotriene D4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Leukotriene D4 ELISA kit

E01L0287-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Leukotriene D4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Leukotriene E4 ELISA kit

E01L0289-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Leukotriene E4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Leukotriene E4 ELISA kit

E01L0289-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Leukotriene E4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Leukotriene E4 ELISA kit

E01L0289-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Leukotriene E4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human leukotriene E4 ELISA kit

55R-1976 96 tests
EUR 658
Description: ELISA Kit for detection of leukotriene E4 in the research laboratory

Human Leukotriene,LT ELISA Kit

YLA2856HU-48T 48T Ask for price

Human Leukotriene,LT ELISA Kit

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Human Leukotriene(LT)ELISA Kit

GA-E1970HM-48Tests 48 Tests Ask for price

Human Leukotriene(LT)ELISA Kit

GA-E1970HM-96Tests 96 Tests
EUR 388

Human Leukotriene B4 ELISA Kit

ELA-E0562h 96tests
EUR 696

Human Leukotriene C4 ELISA Kit

ELA-E0619h 96tests
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Human leukotriene D4 ELISA Kit

ELA-E0935h 96tests
EUR 696

Human Leukotriene(LT)ELISA Kit

GA-E1970HM-48T 48T
EUR 346.8

Human Leukotriene(LT)ELISA Kit

GA-E1970HM-96T 96T
EUR 559.2

Human Leukotriene(LT)ELISA Kit

QY-E04253 96T
EUR 433.2

Human Leukotriene D4 ELISA Kit

MBS725498-10x96StripWells 10x96-Strip-Wells
EUR 5685

Human Leukotriene D4 ELISA Kit

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Human Leukotriene D4 ELISA Kit

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EUR 3020

Human Leukotriene D4 ELISA Kit

MBS725498-96StripWells 96-Strip-Wells
EUR 690

Human Leukotriene B4 ELISA Kit

MBS727205-10x96StripWells 10x96-Strip-Wells
EUR 5685

Human Leukotriene B4 ELISA Kit

MBS727205-48StripWells 48-Strip-Wells
EUR 485

Human Leukotriene B4 ELISA Kit

MBS727205-5x96StripWells 5x96-Strip-Wells
EUR 3020

Human Leukotriene B4 ELISA Kit

MBS727205-96StripWells 96-Strip-Wells
EUR 690

Human Leukotriene C4 ELISA Kit

MBS730206-10x96StripWells 10x96-Strip-Wells
EUR 5685

Human Leukotriene C4 ELISA Kit

MBS730206-48StripWells 48-Strip-Wells
EUR 485

Human Leukotriene C4 ELISA Kit

MBS730206-5x96StripWells 5x96-Strip-Wells
EUR 3020

Human Leukotriene C4 ELISA Kit

MBS730206-96StripWells 96-Strip-Wells
EUR 690

Human Leukotriene A4 ELISA Kit

MBS7220316-10x96StripWells 10x96-Strip-Wells
EUR 5685

 

The choice pathway of complement amplified complement deposition. Deposited C3 fragments coated the activating IgG anti-αGal, obstructing its detection and highlighting this as a possible common caveat in research of antibody density and complement deposition.
                     

 

 

The inherent capability for complement activation by the purified carbohydrate reactive IgG anti-αGal was much like that of regular human IgG. We suggest that the beforehand reported complement inhibition by IgG anti-αGal pertains to suboptimal assay configurations, in distinction to the complement activating property of the antibodies demonstrated on this paper.